Improving Tirapazamine (TPZ) to Target and Eradicate Hypoxia Tumors by Gold Nanoparticle Carriers

• Egile Nagusiak: Giimel Ajnai (Egilea), Chun-Chia Cheng (Egilea), Tzu-Chun Kan (Egilea), Jeng-Wei Lu (Egilea), Sri Rahayu (Egilea), Amy Chiu (Egilea), Jungshan Chang (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Tumor hypoxia is a hallmark of solid tumors and emerged as the therapeutic target for cancer treatments, such as a prodrug Tirapazamine (TPZ) activated in hypoxia. To increase tumor accumulation, gold nanoparticles (GNPs) were selected to conjugate with TPZ. In this study, we successfully formulated...