Improving Tirapazamine (TPZ) to Target and Eradicate Hypoxia Tumors by Gold Nanoparticle Carriers

• Päätekijät: Giimel Ajnai (Tekijä), Chun-Chia Cheng (Tekijä), Tzu-Chun Kan (Tekijä), Jeng-Wei Lu (Tekijä), Sri Rahayu (Tekijä), Amy Chiu (Tekijä), Jungshan Chang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Tumor hypoxia is a hallmark of solid tumors and emerged as the therapeutic target for cancer treatments, such as a prodrug Tirapazamine (TPZ) activated in hypoxia. To increase tumor accumulation, gold nanoparticles (GNPs) were selected to conjugate with TPZ. In this study, we successfully formulated...