Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways

• Hauptverfasser: Ming Fang (Verfasst von), Wen-hong Zhong (Verfasst von), Wen-liang Song (Verfasst von), Yi-yu Deng (Verfasst von), Duo-meng Yang (Verfasst von), Bin Xiong (Verfasst von), Hong-ke Zeng (Verfasst von), Hua-dong Wang (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Schlagworte: article
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Background: Increased permeability of pulmonary capillary is a common consequence of sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor (UTI), is used clinically to mitigate pulmonary edema caused by sepsis. However, the underlying mechanism of UTI i...