Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways

• Автори: Ming Fang (Автор), Wen-hong Zhong (Автор), Wen-liang Song (Автор), Yi-yu Deng (Автор), Duo-meng Yang (Автор), Bin Xiong (Автор), Hong-ke Zeng (Автор), Hua-dong Wang (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Increased permeability of pulmonary capillary is a common consequence of sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor (UTI), is used clinically to mitigate pulmonary edema caused by sepsis. However, the underlying mechanism of UTI i...