Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

• Main Authors: Mohammed M. Alanazi (Author), Ibrahim H. Eissa (Author), Nawaf A. Alsaif (Author), Ahmad J. Obaidullah (Author), Wael A. Alanazi (Author), Abdullah F. Alasmari (Author), Hussam Albassam (Author), Hazem Elkady (Author), Alaa Elwan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour propagation. Accordingly, two series of new 3-methylquinoxaline derivatives have been designed and synthesised as VEGFR-2 inhibi...