Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics

• Main Authors: Emmanuel Chigutsa (Author), Siva Rama Prasad Kambhampati (Author), Amanda Karen Sykes (Author), Maria M. Posada (Author), Jan‐Stefan van derWalt (Author), P. Kellie Turner (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abemaciclib is an oral anticancer drug that inhibits cyclin dependent kinases 4 and 6 and is metabolized by cytochrome P450 3A in the intestines and liver to active metabolites. The objectives were (1) to develop a mechanistic model to characterize the pharmacokinetics (PK) of the active moieties an...