Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics
Abemaciclib is an oral anticancer drug that inhibits cyclin dependent kinases 4 and 6 and is metabolized by cytochrome P450 3A in the intestines and liver to active metabolites. The objectives were (1) to develop a mechanistic model to characterize the pharmacokinetics (PK) of the active moieties an...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2020-09-01T00:00:00Z.
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