Inhibition of High K+-Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle: Possible Involvement of ROCKs in a Signal Transduction Pathway

• Main Authors: Kazuyuki Sakamoto (Author), Masatoshi Hori (Author), Masanori Izumi (Author), Tatsuya Oka (Author), Kazuhiro Kohama (Author), Hiroshi Ozaki (Author), Hideaki Karaki (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the isolated rat aorta, a ROCKs (rhoA-dependent coiled coil serine/threonine kinases) inhibitor, Y-27632, inhibited the contractions induced not only by receptor agonists but also by high K+ with the similar IC50 values (0.8 - 4.9 μM). However, Y-27632 did not inhibit the increment of cytosolic C...