Inhibition of High K+-Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle: Possible Involvement of ROCKs in a Signal Transduction Pathway
In the isolated rat aorta, a ROCKs (rhoA-dependent coiled coil serine/threonine kinases) inhibitor, Y-27632, inhibited the contractions induced not only by receptor agonists but also by high K+ with the similar IC50 values (0.8 - 4.9 μM). However, Y-27632 did not inhibit the increment of cytosolic C...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2003-01-01T00:00:00Z.
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