New insights into the mechanism of antifungal action of 8-hydroxyquinolines

• Main Authors: Bruna Pippi (Author), William Lopes (Author), Paula Reginatto (Author), Fernanda Émili Klein Silva (Author), Angélica Rocha Joaquim (Author), Ricardo José Alves (Author), Gustavo Pozza Silveira (Author), Marilene Henning Vainstein (Author), Saulo Fernandes Andrade (Author), Alexandre Meneghello Fuentefria (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic acid, and 8-hydroxy-7-iodo-5-quinolinesulfonic...