A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)

• Main Authors: Tereza Cristina Santos Evangelista (Author), Óscar López (Author), Adrián Puerta (Author), Miguel X. Fernandes (Author), Sabrina Baptista Ferreira (Author), José M. Padrón (Author), José G. Fernández-Bolaños (Author), Magne O. Sydnes (Author), Emil Lindbäck (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated as inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase...