The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

Statins efficiently inhibit cholesterol synthesis by blocking 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the mevalonate pathway. However, the effect of statins on intracellular cholesterol is partially counterbalanced by a consequent increased uptake of extracellular lipid sources. Hepatitis...

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Main Authors: Tiziana Vescovo (Author), Giulia Refolo (Author), Matteo Ciancio Manuelli (Author), Giuseppe Tisone (Author), Mauro Piacentini (Author), Gian Maria Fimia (Author)
Format: Book
Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
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3rd Floor Main Library

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