Synthesis and Initial In Vivo Evaluation of [¹¹C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R)

• Main Authors: Sean S. Tanzey (Author), Xia Shao (Author), Jenelle Stauff (Author), Janna Arteaga (Author), Phillip Sherman (Author), Peter J. H. Scott (Author), Andrew V. Mossine (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Positron emission tomography (PET) imaging of Colony Stimulating Factor 1 Receptor (CSF1R) is a new strategy for quantifying both neuroinflammation and inflammation in the periphery since CSF1R is expressed on microglia and macrophages. AZ683 has high affinity for CSF1R (K<i><sub>i</s...