Superiority of focused ion beam‐scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity

• Main Authors: Jacqueline Heinen‐Weiler (Author), Mike Hasenberg (Author), Martin Heisler (Author), Stephan Settelmeier (Author), Anna‐Lena Beerlage (Author), Hannah Doepper (Author), Bernd Walkenfort (Author), Andrea Odersky (Author), Peter Luedike (Author), Elke Winterhager (Author), Tienush Rassaf (Author), Ulrike B. Hendgen‐Cotta (Author)
• Format: Book
• Published: Wiley, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostl...