Identification and Characterization of an eIF4e DNA Aptamer That Inhibits Proliferation With High Throughput Sequencing

• Main Authors: Wei Mei Guo (Author), Kiat Whye Kong (Author), Christopher John Brown (Author), Soo Tng Quah (Author), Hui Ling Yeo (Author), Shawn Hoon (Author), Yiqi Seow (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of DNA aptamer screens that are both simple and informative can increase the success rate of DNA aptamer selection and induce greater adoption. High eIF4e levels contribute to malignancies, thus eIF4e presents itself as a valuable target for DNA aptamer-based inhibition screen. Here, we...