Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis

• Main Authors: Yuying Feng (Author), Rongshuang Huang (Author), Fan Guo (Author), Yan Liang (Author), Jin Xiang (Author), Song Lei (Author), Min Shi (Author), Lingzhi Li (Author), Jing Liu (Author), Yanhuan Feng (Author), Liang Ma (Author), Ping Fu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylase 6 (HDAC6) contributed to the pathogenesis of rhabdomyolysis-induced acute kidney injury (AKI) and selective inhibition of HDAC6 activity may be a promising strategy for the treatment of AKI. Compound 23BB as a highly selective HDAC6 inhibitor was designed, synthesized by our lab...