ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response

• Main Authors: Yifei Liu (Author), Lei Zhang (Author), Shumin Zhang (Author), Jialu Liu (Author), Xiaohui Li (Author), Kexin Yang (Author), Danyi Yang (Author), Yu Liu (Author), Lin Sun (Author), Fuyou Liu (Author), Li Xiao (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mitochondrial quality control (MQC) plays a critical role in the progression of tubulointerstitial injury in diabetic kidney disease (DKD). The mitochondrial unfolded protein response (UPRmt), which is an important MQC process, is activated to maintain mitochondrial protein homeo...