In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

• Main Authors: Naresh Podila (Author), Mithun Rudrapal (Author), Subramanyam Sibbala (Author), Atul R. Bendale (Author), Yanadaiah Palakurthi (Author), Molakpogu Ravindra Babu (Author), Kiran Manda (Author), Renzon Daniel Cosme Pecho (Author), Sreelatha Muddisett (Author)
• Format: Book
• Published: Pensoft Publishers, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds wit...