Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.

• Main Authors: Irene Kuepfer (Author), Caecilia Schmid (Author), Mpairwe Allan (Author), Andrew Edielu (Author), Emma P Haary (Author), Abbas Kakembo (Author), Stafford Kibona (Author), Johannes Blum (Author), Christian Burri (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OBJECTIVE: Assessment of the safety and efficacy of a 10-day melarsoprol schedule in second stage T.b. rhodesiense patients and the effect of suramin-pretreatment on the incidence of encephalopathic syndrome (ES) during melarsoprol therapy. DESIGN: Sequential conduct of a proof-of-concept trial (n =...