Computational design and validation of siRNA molecules to silence oncogenic CTNNB1 mRNA as a potential therapeutic strategy against hepatitis B/C virus-associated hepatocellular carcinoma

• Main Authors: Lauren Emily Fajardo (Author), Mark Andrian Macalalad (Author), Nyzar Mabeth Odchimar (Author), John Christian de Guzman (Author), Fredmoore Orosco (Author)
• Format: Book
• Published: Pensoft Publishers, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The majority of hepatocellular carcinoma cases are caused by infection with hepatitis B (HBV) or C (HCV) viruses. CTNNB1 is the most mutated oncogene in HBV- and HCV-associated tumors. CTNNB1 mutations can lead to β-catenin accumulation, resulting in tumor progression. Small interfering RNAs (siRNAs...