High Prevalence of Multidrug-Resistant <i>Klebsiella pneumoniae</i> in a Tertiary Care Hospital in Ethiopia
<i>Klebsiella pneumoniae</i> poses an urgent public health threat, causing nosocomial outbreaks in different continents. It has been observed to develop resistance to antimicrobials more easily than most bacteria. These days, multidrug-resistant strains are being increasingly reported fr...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2021-08-01T00:00:00Z.
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| Summary: | <i>Klebsiella pneumoniae</i> poses an urgent public health threat, causing nosocomial outbreaks in different continents. It has been observed to develop resistance to antimicrobials more easily than most bacteria. These days, multidrug-resistant strains are being increasingly reported from different countries. However, studies on the surveillance of multidrug-resistant <i>Klebsiella pneumoniae</i> are very rare in Ethiopia. This study aimed to determine the antimicrobial resistance patterns and magnitude of MDR <i>K. pneumoniae</i> isolates from patients attending or admitted to Tikur Anbessa Specialized Hospital (TASH). A cross-sectional study was conducted from September 2018 to February 2019 at TASH, Addis Ababa, Ethiopia. Identification of <i>K. pneumoniae</i> was done by examining the Gram stain, colony characteristics on MacConkey agar and 5% sheep blood agar, as well as using a series of biochemical tests. Antimicrobial susceptibility testing of the isolates for 21 antimicrobials was done by the Kirby-Bauer disc diffusion technique. Data were double entered using Epidata 3.1 and exported to SPSS version 25 software for analysis. Among the total <i>K. pneumoniae</i> isolates (<i>n</i> = 132), almost all 130 (98.5%) were MDR. Two (1.5%) isolates showed complete non-susceptibility to all antimicrobial agents tested. Moreover, a high rate of resistance was observed to cefotaxime and ceftriaxone 128 (97%), trimethoprim-sulfamethoxazole 124 (93.9%), and cefepime 111 (84.1%). High susceptibility was recorded to amikacin 123 (93.2%), imipenem 107 (81.1%), meropenem 96 (72.7%), and ertapenem 93 (70.5%). <i>K. pneumoniae</i> isolates showed a high rate of resistance to most of the tested antimicrobials. The magnitude of MDR <i>K. pneumoniae</i> was very alarming. Therefore, strengthening antimicrobial stewardship programs and antimicrobial surveillance practices is strongly recommended in TASH. |
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| Item Description: | 10.3390/antibiotics10081007 2079-6382 |