Inhibition of Ca²⁺/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

• Main Authors: Shirahama Masafumi (Author), Ushio Soichiro (Author), Egashira Nobuaki (Author), Yamamoto Shota (Author), Sada Hikaru (Author), Masuguchi Ken (Author), Kawashiri Takehiro (Author), Oishi Ryozo (Author)
• Format: Book
• Published: SAGE Publishing, 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes severe peripheral neuropathy. We previously reported that oxaliplatin (4 mg/kg, i.p., twice a week) induces mechanical allodynia in the late phase in rats...