Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

• Hoofdauteurs: Nirvana A. Gohar (Auteur), Eman A. Fayed (Auteur), Yousry A. Ammar (Auteur), Ola A. Abu Ali (Auteur), Ahmed Ragab (Auteur), Amal M. Mahfoz (Auteur), Moustafa S. Abusaif (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes. Indeno[1,2-b] quinoxalines-carrying thiazole hybrids 1-17 were created and described using NMR. All analogues were tested for...