Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1

• Główni autorzy: Florimar Gil (Autor), Jerónimo Laiolo (Autor), Brayan Bayona-Pacheco (Autor), Richard D. Cannon (Autor), Antonio Ferreira-Pereira (Autor), María Cecilia Carpinella (Autor)
• Format: Książka
• Wydane: BMC, 2022-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background The development of multidrug resistance (MDR) associated with the overexpression of the efflux transporters Mdr1 and Cdr1 in Candida species impedes antifungal therapies. The urgent need for novel agents able to inhibit the function of both pumps, led us to evaluate this property...