Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

• Main Authors: Chang Yan (Author), Zhuo Luo (Author), Wen Li (Author), Xue Li (Author), Robert Dallmann (Author), Hiroshi Kurihara (Author), Yi-Fang Li (Author), Rong-Rong He (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues via nerve termini. The viral genome is th...