Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner

• Main Authors: Wei Qu (Author), Li Fan (Author), Yun-chul Kim (Author), Shizuma Ishikawa (Author), Sanae M.M. Iguchi-Ariga (Author), Xiao-Ping Pu (Author), Hiroyoshi Ariga (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: DJ-1, a causative gene product of a familial form of Parkinson's disease (PD), PARK7, plays a role in anti-oxidative stress, and loss of its function is thought to result in the onset of PD. Superfluous oxidation of cysteine at amino acid 106 (C106) of DJ-1 renders DJ-1 inactive, and...