Novel Nanoparticles Based on <i>N</i>,<i>O</i>-Carboxymethyl Chitosan-Dopamine Amide Conjugate for Nose-to-Brain Delivery

• Main Authors: Adriana Trapani (Author), Stefania Cometa (Author), Elvira De Giglio (Author), Filomena Corbo (Author), Roberta Cassano (Author), Maria Luisa Di Gioia (Author), Sonia Trombino (Author), Md Niamat Hossain (Author), Sante Di Gioia (Author), Giuseppe Trapani (Author), Massimo Conese (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A widely investigated approach to bypass the blood brain barrier is represented by the intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections nose-brain. As for Parkinson's disease (PD), characterized by dopaminergic midbrain neurons degeneration, currently...