A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells

• Main Authors: Yoshitaka Murota (Author), Mariko Nagane (Author), Mei Wu (Author), Mithun Santra (Author), Seshasailam Venkateswaran (Author), Shinji Tanaka (Author), Mark Bradley (Author), Tetsuya Taga (Author), Kouichi Tabu (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant to anti-cancer drugs and a deeper understanding of their microenvironmental niche has been considered important...