Designing phase I oncology dose escalation using dose-exposure-toxicity models as a complementary approach to model‐based dose-toxicity models

• Main Authors: Kristyn Pantoja (Author), Shankar Lanke (Author), Alain Munafo (Author), Anja Victor (Author), Christina Habermehl (Author), Armin Schueler (Author), Karthik Venkatakrishnan (Author), Pascal Girard (Author), Kosalaram Goteti (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2022-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract One of the objectives of oncology phase I dose‐escalation studies has been to determine the maximum tolerated dose (MTD). Although MTD is no longer set as the dose for further development in contemporary oncology drug development, MTD determination is still important for informing the thera...