Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

• Glavni autori: Tareq Abu-Izneid (Autor), Muhammad Abbas (Autor), David G. Watson (Autor), Yasar Shah (Autor), Sayyed I. Shah (Autor), Fazli Khuda (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers considerable difficulties. In the present study, DHA...