Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

• Main Authors: Ying Wang (Author), Shinichi Namba (Author), Esteban Lopera (Author), Sini Kerminen (Author), Kristin Tsuo (Author), Kristi Läll (Author), Masahiro Kanai (Author), Wei Zhou (Author), Kuan-Han Wu (Author), Marie-Julie Favé (Author), Laxmi Bhatta (Author), Philip Awadalla (Author), Ben Brumpton (Author), Patrick Deelen (Author), Kristian Hveem (Author), Valeria Lo Faro (Author), Reedik Mägi (Author), Yoshinori Murakami (Author), Serena Sanna (Author), Jordan W. Smoller (Author), Jasmina Uzunovic (Author), Brooke N. Wolford (Author), Cristen Willer (Author), Eric R. Gamazon (Author), Nancy J. Cox (Author), Ida Surakka (Author), Yukinori Okada (Author), Alicia R. Martin (Author), Jibril Hirbo (Author), Kuan-Han H. Wu (Author), Humaira Rasheed (Author), Jibril B. Hirbo (Author), Arjun Bhattacharya (Author), Huiling Zhao (Author), Esteban A. Lopera-Maya (Author), Sinéad B. Chapman (Author), Juha Karjalainen (Author), Mitja Kurki (Author), Maasha Mutaamba (Author), Juulia J. Partanen (Author), Ben M. Brumpton (Author), Sameer Chavan (Author), Tzu-Ting Chen (Author), Michelle Daya (Author), Yi Ding (Author), Yen-Chen A. Feng (Author), Christopher R. Gignoux (Author), Sarah E. Graham (Author), Whitney E. Hornsby (Author), Nathan Ingold (Author), Ruth Johnson (Author), Triin Laisk (Author), Kuang Lin (Author), Jun Lv (Author), Iona Y. Millwood (Author), Priit Palta (Author), Anita Pandit (Author), Michael H. Preuss (Author), Unnur Thorsteinsdottir (Author), Matthew Zawistowski (Author), Xue Zhong (Author), Archie Campbell (Author), Kristy Crooks (Author), Geertruida H. de Bock (Author), Nicholas J. Douville (Author), Sarah Finer (Author), Lars G. Fritsche (Author), Christopher J. Griffiths (Author), Yu Guo (Author), Karen A. Hunt (Author), Takahiro Konuma (Author), Riccardo E. Marioni (Author), Jansonius Nomdo (Author), Snehal Patil (Author), Nicholas Rafaels (Author), Anne Richmond (Author), Jonathan A. Shortt (Author), Peter Straub (Author), Ran Tao (Author), Brett Vanderwerff (Author), Kathleen C. Barnes (Author), Marike Boezen (Author), Zhengming Chen (Author), Chia-Yen Chen (Author), Judy Cho (Author), George Davey Smith (Author), Hilary K. Finucane (Author), Lude Franke (Author), Andrea Ganna (Author), Tom R. Gaunt (Author), Tian Ge (Author), Hailiang Huang (Author), Jennifer Huffman (Author), Jukka T. Koskela (Author), Clara Lajonchere (Author), Matthew H. Law (Author), Liming Li (Author), Cecilia M. Lindgren (Author), Ruth J.F. Loos (Author), Stuart MacGregor (Author), Koichi Matsuda (Author), Catherine M. Olsen (Author), David J. Porteous (Author), Jordan A. Shavit (Author), Harold Snieder (Author), Richard C. Trembath (Author), Judith M. Vonk (Author), David Whiteman (Author), Stephen J. Wicks (Author), Cisca Wijmenga (Author), John Wright (Author), Jie Zheng (Author), Xiang Zhou (Author), Michael Boehnke (Author), Daniel H. Geschwind (Author), Caroline Hayward (Author), Eimear E. Kenny (Author), Yen-Feng Lin (Author), Hilary C. Martin (Author), Sarah E. Medland (Author), Aarno V. Palotie (Author), Bogdan Pasaniuc (Author), Kari Stefansson (Author), David A. van Heel (Author), Robin G. Walters (Author), Sebastian Zöllner (Author), Cristen J. Willer (Author), Mark J. Daly (Author), Benjamin M. Neale (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodol...