Nanocrystal Preparation of Poorly Water-Soluble Drugs with Low Metal Contamination Using Optimized Bead-Milling Technology

• Main Authors: Hironori Tanaka (Author), Yuya Ochii (Author), Yasushi Moroto (Author), Daisuke Hirata (Author), Tetsuharu Ibaraki (Author), Ken-ichi Ogawara (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nanocrystal preparation using bead milling is an important technology to enhance the solubility of poorly water-soluble drugs. However, there are safety concerns regarding the metal contaminants generated during bead milling. We have previously reported optimized bead-milling parameters that could m...