Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course

• Main Authors: Dilara Akhoundova (Author), Stefanie Fischer (Author), Joanna Triscott (Author), Marika Lehner (Author), Phillip Thienger (Author), Sina Maletti (Author), Muriel Jacquet (Author), Dinda S.H. Lubis (Author), Lukas Bubendorf (Author), Wolfram Jochum (Author), Mark A. Rubin (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and...