Preparation and evaluation of Vinpocetine self-emulsifying pH gradient release pellets

• Main Authors: Mengqi Liu (Author), Shiming Zhang (Author), Shuxia Cui (Author), Fen Chen (Author), Lianqun Jia (Author), Shu Wang (Author), Xiumei Gai (Author), Pingfei Li (Author), Feifei Yang (Author), Weisan Pan (Author), Xinggang Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main objective of this study was to develop a pH gradient release pellet with self-emulsifying drug delivery system (SEDDS), which could not only improve the oral bioavailability of Vinpocetine (VIN), a poor soluble drug, but reduce the fluctuation of plasma concentration. First, the liquid VIN...