Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

• Main Authors: Dagmar Schumacher (Author), Jakob Morgenstern (Author), Yoko Oguchi (Author), Nadine Volk (Author), Stefan Kopf (Author), Jan Benedikt Groener (Author), Peter Paul Nawroth (Author), Thomas Fleming (Author), Marc Freichel (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to metabolize MG; however, the relative contribution...