Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

• Main Authors: Ilinca Suciu (Author), Johannes Delp (Author), Simon Gutbier (Author), Anna-Katharina Ückert (Author), Anna-Sophie Spreng (Author), Philipp Eberhard (Author), Christiaan Karreman (Author), Falk Schreiber (Author), Katrin Madjar (Author), Jörg Rahnenführer (Author), Ivana Celardo (Author), Ivano Amelio (Author), Marcel Leist (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, following exposure to MG-132 [100 nM]. This proteasom...