Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

• Autori principali: John C. Burnett (Autore), John J. Rossi (Autore), Jiehua Zhou (Autore), Ka-To Shum (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the de...