Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target

• Main Authors: Melissa E. Rodnick (Author), Carina Sollert (Author), Daniela Stark (Author), Mara Clark (Author), Andrew Katsifis (Author), Brian G. Hockley (Author), D. Christian Parr (Author), Jens Frigell (Author), Bradford D. Henderson (Author), Monica Abghari-Gerst (Author), Morand R. Piert (Author), Michael J. Fulham (Author), Stefan Eberl (Author), Katherine Gagnon (Author), Peter J. H. Scott (Author)
• Format: Book
• Published: SpringerOpen, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose To optimize the direct production of 68Ga on a cyclotron, via the 68Zn(p,n)68Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68Ga, extraction of [68Ga]GaCl3 and subsequent [68Ga]Ga-PSMA-11 labeling using an automated synthesis module. Met...