Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

• Главные авторы: Fumito Wada (Автор), Tsuyoshi Yamamoto (Автор), Tadayuki Kobayashi (Автор), Keisuke Tachibana (Автор), Kosuke Ramon Ito (Автор), Mayumi Hamasaki (Автор), Yukina Kayaba (Автор), Chisato Terada (Автор), Asako Yamayoshi (Автор), Satoshi Obika (Автор), Mariko Harada-Shiba (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2021-12-01T00:00:00Z.
• Предметы: article
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Antisense oligonucleotides (ASOs) containing bridged nucleic acids (BNAs) have been proven to be very powerful. However, ensuring a reliable discovery and translational development scheme for this class of ASOs with wider therapeutic windows remains a fundamental challenge. We here demonstrate the r...