Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

• Main Authors: Fumito Wada (Author), Tsuyoshi Yamamoto (Author), Tadayuki Kobayashi (Author), Keisuke Tachibana (Author), Kosuke Ramon Ito (Author), Mayumi Hamasaki (Author), Yukina Kayaba (Author), Chisato Terada (Author), Asako Yamayoshi (Author), Satoshi Obika (Author), Mariko Harada-Shiba (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense oligonucleotides (ASOs) containing bridged nucleic acids (BNAs) have been proven to be very powerful. However, ensuring a reliable discovery and translational development scheme for this class of ASOs with wider therapeutic windows remains a fundamental challenge. We here demonstrate the r...