Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

• Main Authors: Alexandra Kasabova-Angelova (Author), Magdalena Kondeva-Burdina (Author), Javor Mitkov (Author), Maya Georgieva (Author), Virginia Tzankova (Author), Alexander Zlatkov (Author)
• Format: Book
• Published: Universidade de São Paulo, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neu...