Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study

Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study

Excessive activation of the mineralocorticoid receptor (MR) underlies the pathophysiology of heart failure and chronic kidney disease. Hyperkalemia risk limits the therapeutic use of conventional MR antagonists. AZD9977 is a nonsteroidal, selective MR modulator that may protect nonepithelial tissues...

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Main Authors: Andrew Whittaker (Author), Åsa M. Kragh (Author), Judith Hartleib‐Geschwindner (Author), Muna Albayaty (Author), Anna Backlund (Author), Peter J. Greasley (Author), Maria Heijer (Author), Magnus Kjaer (Author), Pablo Forte (Author), Robert Unwin (Author), Linda Wernevik (Author), Hans Ericsson (Author)
Format: Book
Published: Wiley, 2020-03-01T00:00:00Z.
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