Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer

• Main Authors: David S. P. Cardoso (Author), Nikoletta Szemerédi (Author), Gabriella Spengler (Author), Silva Mulhovo (Author), Daniel J. V. A. dos Santos (Author), Maria-José U. Ferreira (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dregamine (<b>1</b>), a major monoterpene indole alkaloid isolated from <i>Tabernaemontana elegans,</i> was submitted to chemical transformation of the ketone function, yielding 19 azines (<b>3</b>-<b>21</b>) and 11 semicarbazones (<b>22</b>...