Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer

• Váldodahkkit: David S. P. Cardoso (Dahkki), Nikoletta Szemerédi (Dahkki), Gabriella Spengler (Dahkki), Silva Mulhovo (Dahkki), Daniel J. V. A. dos Santos (Dahkki), Maria-José U. Ferreira (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Dregamine (<b>1</b>), a major monoterpene indole alkaloid isolated from <i>Tabernaemontana elegans,</i> was submitted to chemical transformation of the ketone function, yielding 19 azines (<b>3</b>-<b>21</b>) and 11 semicarbazones (<b>22</b>...