H4K20 monomethylation inhibition causes loss of genomic integrity in mouse preimplantation embryos

• Main Authors: Daiki SHIKATA (Author), Takuto YAMAMOTO (Author), Shinnosuke HONDA (Author), Shuntaro IKEDA (Author), Naojiro MINAMI (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maintaining genomic integrity in mammalian early embryos, which are deficient in DNA damage repair, is critical for normal preimplantation and subsequent development. Abnormalities in DNA damage repair in preimplantation embryos can cause not only developmental arrest, but also diseases such as cong...