Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia

• Main Authors: Mengying Zheng (Author), Bingnan Liu (Author), Yuanyuan Shao (Author), Luogang Hua (Author), Rong Fu (Author), Huaquan Wang (Author), Ting Wang (Author), Weiwei Qi (Author), Zonghong Shao (Author), Chunyan Liu (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on the functions of myeloid dendritic cells (mDCs) in a mouse model of severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. Flow cytometry and qPCR were used to de...