Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity

• Main Authors: Ayumi Fukakusa (Author), Hiroyuki Mizoguchi (Author), Hiroyuki Koike (Author), Toshitaka Nabeshima (Author), Kazuhiro Takuma (Author), Kiyofumi Yamada (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-de...