Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity
To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-de...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2008-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_abd51f5e1b8c4e788cf5586c88627e02 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ayumi Fukakusa |e author |
| 700 | 1 | 0 | |a Hiroyuki Mizoguchi |e author |
| 700 | 1 | 0 | |a Hiroyuki Koike |e author |
| 700 | 1 | 0 | |a Toshitaka Nabeshima |e author |
| 700 | 1 | 0 | |a Kazuhiro Takuma |e author |
| 700 | 1 | 0 | |a Kiyofumi Yamada |e author |
| 245 | 0 | 0 | |a Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity |
| 260 | |b Elsevier, |c 2008-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.SC0070328 | ||
| 520 | |a To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA−/−), and protease activated receptor-1-deficient (PAR-1−/−) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo. Keywords:: methamphetamine, neurotoxicity, tissue plasminogen activator | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 106, Iss 2, Pp 321-324 (2008) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319340964 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/abd51f5e1b8c4e788cf5586c88627e02 |z Connect to this object online. |