Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation

• Main Authors: Nancy Sue (Author), Le May Thai (Author), Atsushi Saito (Author), Cierra K. Boyer (Author), Ashleigh M. Fordham (Author), Chenxu Yan (Author), Aimee Davenport (Author), Jiang Tao (Author), Mohammed Bensellam (Author), James Cantley (Author), Yan-Chuan Shi (Author), Samuel B. Stephens (Author), Kazunori Imaizumi (Author), Trevor J. Biden (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum (ER) and incorporation into insulin secretory granules (ISGs). Here we investig...