Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

• Main Authors: Zengxin Jiang (Author), Guobin Qi (Author), Wei Lu (Author), Hao Wang (Author), Defang Li (Author), Weibin Chen (Author), Lei Ding (Author), Xiuying Yang (Author), Hengfeng Yuan (Author), Qingmin Zeng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone is a semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine wheth...