Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity

Cancer is one of the important factors threatening human health. Hence, it is essential to create novel potent drugs to treat it. Due to the strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers, dual inhibition of HDAC1 and SPOP may be a promising strate...

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Main Authors: Yingxue Yang (Author), Shutong Chen (Author), Qinghua Wang (Author), Miao-Miao Niu (Author), Yuanqian Qu (Author), Yang Zhou (Author)
Format: Book
Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
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