Discovery of Novel Dual Adenosine A_2A and A₁ Receptor Antagonists with 1<i>H</i>-Pyrazolo[3,4<i>-d</i>]pyrimidin-6-amine Core Scaffold as Anti-Parkinson's Disease Agents

• Main Authors: Juyoung Jung (Author), Yoonsuk Lee (Author), An-Na Moon (Author), Jihyae Ann (Author), Jin Ju Jeong (Author), Nayeon Do (Author), Jeewoo Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New compounds with 1<i>H</i>-pyrazolo [3,4<i>-d</i>]pyrimidin-6-amine core scaffolds were synthesized and characterized in vitro to determine their affinity for human A_2A and A₁ receptors. Among the tested compounds, a few compoun...