Self-assembly of CXCR4 antagonist peptide-docetaxel conjugates for breast tumor multi-organ metastasis inhibition

• Main Authors: Chen Li (Author), Jiayan Lang (Author), Yazhou Wang (Author), Zhaoxia Cheng (Author), Mali Zu (Author), Fenfen Li (Author), Jingyi Sun (Author), Yating Deng (Author), Tianjiao Ji (Author), Guangjun Nie (Author), Ying Zhao (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a representative chemotherapeutic drug, docetaxel (DTX) has been used for breast cancer treatment for decades. However, the poor solubility of DTX limits its efficacy, and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4 (CXCR4) expres...