Topical Use of Angiopoietin-like Protein 2 RNAi-loaded Lipid Nanoparticles Suppresses Corneal Neovascularization

• Main Authors: Yukako Taketani (Author), Tomohiko Usui (Author), Tetsuya Toyono (Author), Nobuyuki Shima (Author), Seiichi Yokoo (Author), Mikiko Kimakura (Author), Satoru Yamagami (Author), Shinichiro Ohno (Author), Risako Onodera (Author), Kohei Tahara (Author), Hirofumi Takeuchi (Author), Masahiko Kuroda (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Corneal neovascularization (CNV) is a sight-threatening condition that is encountered in various inflammatory settings including chemical injury. We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a s...